Growth Factors & Cytokines

Recombinant Human Gremlin-1

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Product Details

Catalogue Number: 120-42
Description:


Recombinant Human Gremlin-1

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins that bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin-1 is highly expressed in the small intestine, fetal brain, and colon; and is expressed at lower levels in the brain, prostate, pancreas, and in skeletal muscle.  Gremlin-1 regulates multiple functions in early development by specifically binding to, and inhibiting the function of, BMP-2, -4, and -7.  It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Human Gremlin-1 is a 18.3 kDa protein containing 160 amino acid residues.

Source: CHO cells

Synonyms: CKTSF1B1, DAND2, DRM, IHG-2

AA Sequence: KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD

Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells.  The ED50 for this effect is 0.07-0.11 μg/ml.

Calculated Molecular Weight: 18.3 kDa

Accession Number: O60565

Gene ID: 26585

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Chang, S
Title
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.
Citation
Nature Communications; 10(1) pg1442
PubMed Id
First Author
Schang, G
Title
Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells.
Citation
The Journal of Biological Chemistry; 298(7) pg102072
PubMed Id
First Author
Junk, D J
Title
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Citation
Oncogene; 36(28) pg4001-4013
PubMed Id