Recombinant Human IFN-λ1 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-02L Description: IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues. Source: E.coli Synonyms: IL-29 AA Sequence: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml. Calculated Molecular Weight: 19.8 kDa Accession Number: Q8IU54 Gene ID: 282618 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Monkey, Monkey + Virus, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Diabetes/Weight Regulation Immune System product.subtitle.recentcitations First Author Fendereski, M Title Mouse Trophoblast Cells Can Provide IFN-Based Antiviral Protection to Embryonic Stem Cells via Paracrine Signaling. Citation Journal of immunology (Baltimore, Md. : 1950); 208(12) pg2761-2770 PubMed Id 35649628 First Author Sposito, B Title The interferon landscape along the respiratory tract impacts the severity of COVID-19. Citation Cell; 184(19) pg4953-4968.e16 PubMed Id 34492226 First Author Krenn, V Title Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Citation Cell Stem Cell; 28(8) pg1362-1379.e7 PubMed Id 33838105
