Animal-Free Cytokines

Animal-Free Recombinant Human IFN-γ

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Product Details

Catalogue Number: AF-300-02
Description:

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF

AA Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 16.8 kDa

Accession Number: P01579.1

Gene ID: 3458

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Asp, L
Title
Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.
Citation
Journal of inflammation (London, England); 8 pg25
PubMed Id
First Author
Zhao, X W
Title
CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 108(45) pg18342-7
PubMed Id
First Author
Panter, M S
Title
Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.
Citation
The Journal of Biological Chemistry; 287(37) pg31172-84
PubMed Id