Animal-Free Recombinant Human IFN-γ 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-300-02 Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF AA Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 16.8 kDa Accession Number: P01579.1 Gene ID: 3458 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Fish + Virus, Human, Human + Bacteria, Mandarin Fish, Monkey, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Neurobiology Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Liu, W Title hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation. Citation Stem Cells International; 2022 pg1052166 PubMed Id 36277038 First Author Magusali, N Title A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Citation Brain : A Journal Of Neurology; 144(12) pg3727-3741 PubMed Id 34619763 First Author Wang, Y Title Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3) Citation Scientific Reports; 11(1) pg8054 PubMed Id 33850164
