Animal-Free Recombinant Human IFN-β 0 ReviewsSubmit a Review Product Details Catalog Number: AF-300-02B Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. PeproTech’s Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Leukocyte interferon, B cell interferon, Type I interferon AA Sequence: MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 106 units/mg. Calculated Molecular Weight: 20 kDa Accession Number: P01574 Gene ID: 3456 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Neurobiology Recent Citations First Author Evgin, L Title Oncolytic virus-derived type I interferon restricts CAR T cell therapy Citation Nature Communications; 11(1) pg3187 PubMed ID 32581235 First Author Davis, S Title Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway. Citation Scientific Reports; 9(1) pg15485 PubMed ID 31664093 First Author Dangaj, D Title Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Citation Cancer Cell; 35(6) pg885-900.e10 PubMed ID 31185212
