Growth Factors & Cytokines

Recombinant Human IGF-I

Product Details

Catalogue Number: 100-11

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.  IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.  The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.  The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.  IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.  Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.  Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.  Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa.     

Source: E.coli

Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA


Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P05019

Gene ID: 3479

Country Of Origin: USA

Not for human use.

Research Interest


First Author
Hanson, M G
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71
PubMed Id
First Author
Liou, J C
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
The Journal of Physiology; 503 ( Pt 1) pg129-39
PubMed Id
First Author
Goranci-Buzhala, G
Cilium induction triggers differentiation of glioma stem cells.
Cell Reports; 36(10) pg109656
PubMed Id


Existing reviews
IGF-1 for Endometrial Organoid Culture
Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.
Quick Overnight Delivery is great.
From:  Hardik | Date:  31/08/2020