Animal-Free Recombinant Human IL-1β 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-200-01B Description: IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.3 kDa Accession Number: P01584 Gene ID: 3553 crossreactivity: Frog, Human, Monkey, Mouse, Rabbit, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Murahashi, Y Title Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Citation Scientific Reports; 8(1) pg16475 PubMed Id 30405206 First Author Rabenhorst, A Title Mast cells play a protumorigenic role in primary cutaneous lymphoma. Citation Blood; 120(10) pg2042-54 PubMed Id 22837530 First Author Rossato, M Title IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(45) pgE3101-10 PubMed Id 23071313
