Animal-Free Recombinant Human IL-1β 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-200-01B Description: IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.3 kDa Accession Number: P01584 Gene ID: 3553 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Frog, Human, Monkey, Mouse, Rabbit, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Laucirica, D R Title Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection. Citation Immunology and Cell Biology; 100(5) pg352-370 PubMed Id 35318736 First Author Szabo, A Title A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia. Citation Translational Psychiatry; 11(1) pg554 PubMed Id 34716291 First Author Liang, Y Title Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells Citation Scientific Reports; 11(1) pg14720 PubMed Id 34282169