Growth Factors & Cytokines

Recombinant Human IL-15

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Product Details

Catalogue Number: 200-15
Description:

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.  IL-15 exerts its biological activities primarily on T cells.  It is also essential in the development, survival and activation of NK cells.  Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.  Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.  Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: Interleukin-15, IL-T

AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 12.9 kDa

Accession Number: P40933

Gene ID: 3600

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Qi, Q
Title
Diversity and clonal selection in the human T-cell repertoire.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(36) pg13139-44
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Landgraf, K E
Title
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.
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Communications Biology; 3(1) pg296
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First Author
Tilburgs, T
Title
Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.
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Proceedings of the National Academy of Sciences of the United States of America; 112(23) pg7219-24
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