Recombinant Human IL-15 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-15 Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. Source: E.coli Synonyms: Interleukin-15, IL-T AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.9 kDa Accession Number: P40933 Gene ID: 3600 crossreactivity: Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Monkey, Mouse, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell AIDS/HIV Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Sancho, D Title Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15. Citation Blood; 93(3) pg886-96 PubMed Id 9920837 First Author Qin, J Z Title Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells. Citation Blood; 93(1) pg260-7 PubMed Id 9864169 First Author Imada, K Title Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. Citation The Journal of Experimental Medicine; 188(11) pg2067-74 PubMed Id 9841920
