Growth Factors & Cytokines

Recombinant Human IL-17F

Product Details

Catalogue Number: 200-25
Description:

IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate the proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. The mature human IL-17F is a homodimeric protein with a total weight of 30.1 kDa, consisting of two 133 amino acid residue chains. E.coli-derived Recombinant Human IL-17F is a biologically active, non-glycosylated, disulfide-linked homodimeric protein containing 268 amino acids (30.1 kDa), including N-terminal methionine residues.

Source: E.coli

Synonyms: Interleukin-17F

AA Sequence (monomer): MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-6 production by NHDF cells.

Calculated Molecular Weight: 30.1 kDa

Accession Number: Q96PD4

Gene ID: 112744

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
De Simone, V
Title
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
Citation
Oncogene; 34(27) pg3493-503
PubMed Id
First Author
Boggio, E
Title
IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes.
Citation
Blood; 123(8) pg1178-86
PubMed Id
First Author
Edwards, L A
Title
Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.
Citation
PLoS ONE; 5(11) pge15398
PubMed Id