Recombinant Human IL-19 0 ReviewsSubmit a Review Product Details Catalog Number: 200-19 Description: IL-19 belongs to the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine, because it up-regulates IL-6 and TNF-α, and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant Human IL-19 is a 35.8 kDa homodimer of two 154 amino acid chains. In solution, IL-19 exists predominantly as a non-disulfide-linked dimer. Source: E.coli Synonyms: Interleukin-19, Melanoma differentiation association like protein AA Sequence (monomer): MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction. Calculated Molecular Weight: 35.8 kDa Accession Number: Q9UHD0 Gene ID: 29949 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Immune System Inflammation Recent Citations First Author Zenewicz, L A Title Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Citation Immunity; 29(6) pg947-57 PubMed ID 19100701 First Author Jordan, W J Title Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10. Citation European Journal of Immunology; 35(5) pg1576-82 PubMed ID 15827959
