Recombinant Human IL-22 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-22 Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18 AA Sequence (monomer): MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Determined by its ability to activate STAT following receptor ligand interaction. Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/ml. Calculated Molecular Weight: 33.6 kDa Accession Number: Q9GZX6 Gene ID: 50616 crossreactivity: Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System product.subtitle.recentcitations First Author Fujii, S Title PGE Citation Scientific Reports; 6 pg36795 PubMed Id 27827428 First Author Edwards, L A Title Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. Citation PLoS ONE; 5(11) pge15398 PubMed Id 21085698 First Author Bouhaddou, M Title The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Citation Cell; 182(3) pg685-712.e19 PubMed Id 32645325