Recombinant Human IL-34 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-34 Description: IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag. Source: HEK293 cells Synonyms: Interleukin-34, C16orf77 AA Sequence (monomer): NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce secretion of MCP-1 from PBMCs. Calculated Molecular Weight: 52.5 kDa Accession Number: Q6ZMJ4 Gene ID: 146433 Note: 1mg will be provided as 2x500μg. crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Bone, Skeletal, Cartilage Cancer Immune System Inflammation product.subtitle.recentcitations First Author Nzou, G Title Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Citation Scientific Reports; 8(1) pg7413 PubMed Id 29743549 First Author Konttinen, H Title PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Citation Stem Cell Reports; 13(4) pg669-683 PubMed Id 31522977 First Author Liu, T Title Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. Citation The Journal of Experimental Medicine; 217(12) PubMed Id 32941599 product.subtitle.productreviews Existing reviews IL-34 for microglia differentiation Our lab has been successfully using IL-34 to differentiate stem cells into microglia for over 1.5 year. This product goes through a rigorous quality control and always gets delivered in a timely manner. From: Morgane | Date: 21/07/2020 × IL-34 for microglia differentiation Our lab has been successfully using IL-34 to differentiate stem cells into microglia for over 1.5 year. This product goes through a rigorous quality control and always gets delivered in a timely manner. From: Morgane | Date: 21/07/2020 Close
