Recombinant Human IL-34 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-34 Description: IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag. Source: HEK293 cells Synonyms: Interleukin-34, C16orf77 AA Sequence (monomer): NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce secretion of MCP-1 from PBMCs. Calculated Molecular Weight: 52.5 kDa Accession Number: Q6ZMJ4 Gene ID: 146433 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Bone, Skeletal, Cartilage Cancer Immune System Inflammation product.subtitle.recentcitations First Author Park, J Title Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(23) pge2201212 PubMed Id 35694866 First Author Sabate-Soler, S Title Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Citation Glia; 70(7) pg1267-1288 PubMed Id 35262217 First Author Magusali, N Title A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Citation Brain : A Journal Of Neurology; 144(12) pg3727-3741 PubMed Id 34619763 product.subtitle.productreviews Existing reviews IL-34 for microglia differentiation Our lab has been successfully using IL-34 to differentiate stem cells into microglia for over 1.5 year. This product goes through a rigorous quality control and always gets delivered in a timely manner. From: Morgane | Date: 21/07/2020 × IL-34 for microglia differentiation Our lab has been successfully using IL-34 to differentiate stem cells into microglia for over 1.5 year. This product goes through a rigorous quality control and always gets delivered in a timely manner. From: Morgane | Date: 21/07/2020 Close
