Recombinant Human IL-36β (IL-1F8) 0 ReviewsSubmit a Review Product Details Catalog Number: 200-36B Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-κB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36β is a 17.3 kDa protein containing 154 amino acid residues. Source: E.coli Synonyms: Interleukin-36β, IL-1F8 , IL-1H2, IL-1 eta AA Sequence: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-8 production by human PBMCs. Calculated Molecular Weight: 17.3 kDa Accession Number: Q9NZH7 Gene ID: 27177 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Recent Citations First Author Ahsan, F Title IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis. Citation Scientific Reports; 8(1) pg1520 PubMed ID 29367626
