Animal-Free Recombinant Human IL-4 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-04 Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1) AA Sequence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. Calculated Molecular Weight: 15.1 kDa Accession Number: P05112 Gene ID: 3565 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids COVID-19 Apoptosis Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Allergy Transplantation Recent Citations First Author Valero, J G Title The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma Citation Leukemia; 35(9) pg2635-2649 PubMed ID 33731849 First Author Wang, S Title USP24 promotes drug resistance during cancer therapy Citation Cell Death and Differentiation; 28(9) pg2690-2707 PubMed ID 33846536 First Author Creelan, B C Title Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial Citation Nature Medicine; 27(8) pg1410-1418 PubMed ID 34385708
