Animal-Free Recombinant Human IL-6 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-06 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 20.9 kDa Accession Number: P05231 Gene ID: 3569 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation Recent Citations First Author Amri, N Title Blood Endothelial-Cell Extracellular Vesicles as Potential Biomarkers for the Selection of Plasma in COVID-19 Convalescent Plasma Therapy. Citation Cells; 11(19) PubMed ID 36231083 First Author Luan, X Title Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway. Citation FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 35(11) pge21958 PubMed ID 34606626 First Author Eernstman, J Title Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals Citation Scientific Reports; 11(1) pg18557 PubMed ID 34535703
