Animal-Free Recombinant Human IL-6 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-200-06 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 20.9 kDa Accession Number: P05231 Gene ID: 3569 crossreactivity: Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Sheng, Z Title BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Citation Blood; 118(10) pg2840-8 PubMed Id 21715304 First Author Ebisudani, T Title Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. Citation Cell Reports; 35(10) pg109218 PubMed Id 34038715 First Author Deng, W Title Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Citation Cell; 149(6) pg1233-44 PubMed Id 22682246
