Chemokines

Recombinant Human IL-8 (CXCL8) (72 a.a.)

Product Details

Catalogue Number: 200-08M
Description:

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: CXCL8, monocyte-derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), NAP-1

AA Sequence: SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: P10145

Gene ID: 3576

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Rosenkilde, M M
Title
Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74.
Citation
The Journal of Biological Chemistry; 274(2) pg956-61
PubMed Id
First Author
van den Berg, R H
Title
The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(12) pg6924-30
PubMed Id
First Author
Petersen, F
Title
A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4347-55
PubMed Id