Recombinant Human IL-9 0 ReviewsSubmit a Review Product Details Catalog Number: 200-09 Description: IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant Human IL-9 is a 14.0 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins. Source: E.coli Synonyms: p40 cytokine, T-cell growth factor p40 AA Sequence: MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of human M07e cells was ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. Calculated Molecular Weight: 14 kDa Accession Number: P15248 Gene ID: 3578 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Recent Citations First Author Tvorogov, D Title Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. Citation EMBO reports; 23(4) pge52904 PubMed ID 35156745 First Author Georgolopoulos, G Title Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation. Citation Nature Communications; 12(1) pg6790 PubMed ID 34815405 First Author Das, S Title IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility. Citation Journal of immunology (Baltimore, Md. : 1950); 206(11) pg2740-2752 PubMed ID 34021045
