Growth Factors & Cytokines

Recombinant Human IL-9

Product Details

Catalogue Number: 200-09
Description:

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes.  IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines.  Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease.  Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells.  Recombinant Human IL-9 is a 14.0 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins.

Source: E.coli

Synonyms: p40 cytokine, T-cell growth factor p40

AA Sequence: MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of human M07e cells was ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight: 14 kDa

Accession Number: P15248

Gene ID: 3578

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Yu, H
Title
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Citation
Blood; 92(10) pg3647-57
PubMed Id
First Author
Das, S
Title
IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility.
Citation
Journal of immunology (Baltimore, Md. : 1950); 206(11) pg2740-2752
PubMed Id
First Author
Meyer, L K
Title
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Citation
Blood; 136(6) pg657-668
PubMed Id