Growth Factors & Cytokines

Recombinant Human KGF (FGF-7)

Product Details

Catalogue Number: 100-19
Description:

KGF (FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF-7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF (FGF-7) signals through FGFR 2b. KGF (FGF-7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing. Recombinant Human KGF (FGF-7) is an 18.9 kDa protein consisting of 163 amino acid residues.

Source: E.coli

Synonyms: Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7

AA Sequence: CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.1-15 ng/ml.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 18.9 kDa

Accession Number: P21781

Gene ID: 2252

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Jaakkola, P
Title
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
Citation
FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 12(11) pg959-69
PubMed Id
First Author
Hu, H
Title
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Citation
Cancer Cell; 39(11) pg1531-1547.e10
PubMed Id
First Author
Sharma, K
Title
Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model.
Citation
Cell Reports; 36(3) pg109351
PubMed Id

product.subtitle.productreviews

Existing reviews
It works well
It works well both in human and mouse organoid culture.
From:  Eun Joo | Date:  08/07/2020
Excellent quality
We utilize FGF7 as part of lung cancer organoid media for cancers which do not have EGFR mutations. We have had great results and excellent service.
From:  Dora | Date:  24/07/2020
Great for organoids!
We use this in two types patient tumor organoid media and have wonderful results in each.
From:  Julie-Ann | Date:  03/08/2021