Growth Factors & Cytokines

Recombinant Human Maspin

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Product Details

Catalogue Number: 130-12
Description:
Recombinant Human Maspin

Maspin (mammary serine protease inhibitor) is a non-inhibitory serpin that is expressed predominantly in normal mammary epithelial cells, but at significantly reduced levels or absent in most breast carcinomas. It has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the contribution of maspin to the inhibition of angiogenesis, and its ability to preferentially promote apoptosis of tumor cells. Recombinant Human Maspin is a 42.1 kDa non-glycosylated protein containing 375 amino acid residues.

Source: E.coli

Synonyms: SerpinB5, Protease inhibitor 5

AA Sequence: MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP

Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 42.1 kDa

Accession Number: P36952

Gene ID: 5268

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Reina, J
Title
Identification of a putative nuclear localization signal in the tumor suppressor maspin sheds light on its nuclear import regulation.
Citation
FEBS Open Bio; 9(7) pg1174-1183
PubMed Id