Animal-Free Recombinant Human β-NGF 0 ReviewsSubmit a Review Product Details Catalog Number: AF-450-01 Description: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: NGF-β, beta-Nerve Growth Factor AA Sequence (monomer): SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 27 kDa Accession Number: P01138 Gene ID: 4803 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Chicken, Hamster, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Chemotaxis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Moses, C Title Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing Citation Scientific Reports; 10(1) pg11393 PubMed ID 32647121 First Author Schira-Heinen, J Title Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation Citation Scientific Reports; 10(1) pg3284 PubMed ID 32094412 First Author Cui, Y Title Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction. Citation PLoS ONE; 7(1) pge30389 PubMed ID 22272341
