Recombinant Human NNT-1/BCSF-3 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-18 Description: NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B cell hyperplasia associated with increases in serum IgG and IgM. Recombinant Human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues. Source: E.coli Synonyms: Novel Neurtrophin-1/B-Cell-Stimulating Factor-3, Cardiotrophin-like cytokine, Cardiotrophin-like cytokine factor 1 (CLCF1) AA Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml. Calculated Molecular Weight: 22.4 kDa Accession Number: Q9UBD9 Gene ID: 23529 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Chicken, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation Immune System Neurobiology product.subtitle.recentcitations First Author Wang, S Title JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. Citation The Journal of Clinical Investigation; 127(12) pg4498-4515 PubMed Id 29130936 First Author Junk, D J Title Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Citation Oncogene; 36(28) pg4001-4013 PubMed Id 28288136
