Neurotrophins

Recombinant Human Pleiotrophin

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Product Details

Catalogue Number: 450-15
Description:
Recombinant Human Pleiotrophin

Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.

Source: E.coli

Synonyms: PTN, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1)

AA Sequence: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 15.4 kDa

Accession Number: P21246

Gene ID: 5764

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Koutsioumpa, M
Title
Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.
Citation
The Journal of Biological Chemistry; 288(1) pg343-54
PubMed Id
First Author
Koutsioumpa, M
Title
Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolin.
Citation
Vascular Cell; 4 pg4
PubMed Id
First Author
Arnold, N
Title
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Citation
Nature Communications; 10(1) pg5183
PubMed Id