Recombinant Human Relaxin-3 0 ReviewsSubmit a Review Product Details Catalogue Number: 130-10 Description: Relaxin-3 is a secreted protein structurally related to insulin that is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and has also been identified for binding specifically to the LGR7 receptor, previously identified as an “orphan” G protein-coupled receptor. Signaling by relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Human Relaxin-3 is a 5.5 kDa, disulfide-linked, heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain. Source: E.coli Synonyms: H3 relaxin, Insulin-like peptide-7, INSL7 AA Sequence: Alpha chain: DVLAGLSSSC CKWGCSKSEI SSLCBeta chain: RAAPYGVRLC GREFIRAVIF TCGGSRW Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 5.5 kDa Accession Number: Q8WXF3 Gene ID: 117579 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Diabetes/Weight Regulation Lipid Metabolism Neurobiology product.subtitle.recentcitations First Author Alvarez-Jaimes, L Title In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. Citation PLoS ONE; 7(2) pge30792 PubMed Id 22347403