Growth Factors & Cytokines

Recombinant Human Resistin

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 450-19
Description:


Recombinant Human Resistin

Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Human Resistin is a 19.5 kDa, disulfide-linked, homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.

Source: E.coli

Synonyms: FIZZ3, Adipose tissue-specific secretory factor, ADSF

AA Sequence (monomer): SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate lipolysis in cultured human adipocytes. (Ort, T. et al. Endocrinology; 46(5):2200-9)

Calculated Molecular Weight: 19.5 kDa

Accession Number: Q9HD89

Gene ID: 56729

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Jang, J C
Title
Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 114(48) pgE10399-E10408
PubMed Id
First Author
Leivo-Korpela, S
Title
Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma.
Citation
Journal of inflammation (London, England); 8 pg12
PubMed Id
First Author
Calabro, P
Title
Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways.
Citation
Circulation; 110(21) pg3335-40
PubMed Id