Animal-Free Recombinant Human SDF-1α (CXCL12) 0 ReviewsSubmit a Review Product Details Catalog Number: AF-300-28A Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Calculated Molecular Weight: 8 kDa Biological Activity: Determined by its ability to chemoattract IL-2-activated human T cells using a concentration range of 20.0-80.0 ng/ml. Accession Number: P48061 Gene ID: 6387 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Egea, V Title Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Citation Cell Death & Disease; 12(6) pg516 PubMed ID 34016957 First Author Weston, C J Title Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. Citation The Journal of Clinical Investigation; 125(2) pg501-20 PubMed ID 25562318 First Author Timár, C I Title Antibacterial effect of microvesicles released from human neutrophilic granulocytes. Citation Blood; 121(3) pg510-8 PubMed ID 23144171
