Recombinant Human TFF-1 0 ReviewsSubmit a Review Product Details Catalog Number: 300-60 Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa, and functions as a gastric-specific tumor suppressor gene. Recombinant Human TFF-1 is a 6.7 kDa monomeric protein consisting of a 60 amino acid polypeptide chain, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. Source: E.coli Synonyms: Trefoil Factor 1 (TFF1), pS2 protein, HP1.A, Breast Cancer Estrogen-Inducible protein (BCEI), PNR2 AA Sequence: EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration 5-10 μg/ml. Calculated Molecular Weight: 6.7 kDa Accession Number: P04155 Gene ID: 7031 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Stem Cells & Differentiation Wound Healing Recent Citations First Author Radiloff, D R Title Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. Citation Proceedings of the National Academy of Sciences of the United States of America; 108(16) pg6591-6 PubMed ID 21451135
