Growth Factors & Cytokines

Recombinant Human TGF-α

Product Details

Catalogue Number: 100-16A
Description:

TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.

Source: E.coli

Synonyms: Transforming Growth Factor-α, Sacroma growth factor, TGF-type I, ETGF

AA Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight: 5.5 kDa

Accession Number: P01135

Gene ID: 7039

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hanson, M G
Title
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71
PubMed Id
First Author
Jaakkola, P
Title
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
Citation
FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 12(11) pg959-69
PubMed Id
First Author
Zhang, B
Title
A new protocol for long-term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
Citation
FEBS Open Bio; 10(9) pg1737-1747
PubMed Id

product.subtitle.productreviews

Existing reviews
High quality and better price
This product worked well for my project.  The price is reasonable and lower than most of vendors.
From:  Jin | Date:  26/08/2020