Animal-Free Recombinant Human TGF-α 0 ReviewsSubmit a Review Product Details Catalog Number: AF-100-16A Description: TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independent transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa), which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Transforming Growth Factor-α, Sarcoma growth factor, TGF-type I, ETGF AA Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. Calculated Molecular Weight: 5.5 kDa Accession Number: P01135 Gene ID: 7039 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Chicken, Horse, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Wang, H Title CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini Citation Cell Discovery; 7(1) pg25 PubMed ID 33867522 First Author Ballester, M Title Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells. Citation Scientific Reports; 9(1) pg17978 PubMed ID 31784643 First Author Chua, V Title Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma Citation EMBO Molecular Medicine; 11(2) PubMed ID 30610113
