Animal-Free Recombinant Human VEGF121 0 ReviewsSubmit a Review Product Details Catalog Number: AF-100-20A Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Vascular Endothelial Growth Factor 121, VPF, VEGF-A AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Calculated Molecular Weight: 28.4 kDa Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml. Accession Number: P15692 Gene ID: 7422 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Chicken, Human, Mouse, Rabbit, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Recent Citations First Author Szczepkowska, A Title Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods. Citation Cell and Tissue Research; 350(1) pg157-66 PubMed ID 22622803 First Author Ferro, F Title Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. Citation PLoS ONE; 7(7) pge41774 PubMed ID 22844522 First Author Sachdeva, R Title Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization. Citation PLoS ONE; 7(11) pge51125 PubMed ID 23226476
