BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
Manufactured using all Animal-Free reagents.
Brain Derived Neurotrophic Factor, Abrineurin
AA Sequence (monomer):
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight:
Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
Not for human use.