Chemokines

Recombinant Murine C10 (CCL6)

Product Details

Catalogue Number: 250-06
Description:

Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant Murine C10 is a 10.7 kDa protein containing 95 amino acid residues.

Source: E.coli

Synonyms: CCL6, MRP-1

AA Sequence: GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract Balb/c mouse spleen MNCs using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 10.7 kDa

Accession Number: P27784

Gene ID: 20305

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Krishnan, V
Title
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1
Citation
Communications Biology; 3(1) pg524
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First Author
Demircioglu, F
Title
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Citation
Nature Communications; 11(1) pg1290
PubMed Id
First Author
Yagawa, Y
Title
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Citation
Scientific Reports; 7(1) pg15996
PubMed Id