Chemokines

Recombinant Murine Eotaxin-2 (CCL24)

Product Details

Catalogue Number: 250-22
Description:

Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3, including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 amino acid residues for the murine homolog, without C-terminal truncation). Eotaxin-2 contains the four conserved cysteine residues present in CC chemokines. Recombinant Murine Eotaxin-2 is a 10.3 kDa protein containing 93 amino acid residues.

Source: E.coli

Synonyms: CCL24, MPIF-2, CkB-6

AA Sequence: VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100 ng/ml.

Calculated Molecular Weight: 10.3 kDa

Accession Number: Q9JKC0

Gene ID: 56221

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Felton, J M
Title
Aiolos regulates eosinophil migration into tissues
Citation
Mucosal Immunology; 14(6) pg1271-1281
PubMed Id
First Author
Karcz, T P
Title
UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
Citation
The Journal of Clinical Investigation; 131(7)
PubMed Id
First Author
Yagawa, Y
Title
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Citation
Scientific Reports; 7(1) pg15996
PubMed Id