Recombinant Murine GM-CSF 4 ReviewsSubmit a Review Product Details Catalogue Number: 315-03 Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues. Source: E.coli Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α AA Sequence: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 14.2 kDa Accession Number: P01587 Gene ID: 12981 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Leech, Mouse, Rat, Trout References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Li, Y Title Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis. Citation Molecular Oncology; 16(15) pg2861-2880 PubMed Id 35665592 First Author Hooper, K M Title V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy. Citation The Journal of Cell Biology; 221(6) PubMed Id 35511089 First Author Diethelm, P Title LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response. Citation European Journal of Immunology; 52(6) pg924-935 PubMed Id 35344223 product.subtitle.productreviews Existing reviews Excellent product We have been using this product for 2 yrs for Bone marrow derived dendritic cell experiments and I never disappointed with the results. I highly recommend this product to our collaborators. From: Chetan | Date: 08/07/2020 × Excellent product We have been using this product for 2 yrs for Bone marrow derived dendritic cell experiments and I never disappointed with the results. I highly recommend this product to our collaborators. From: Chetan | Date: 08/07/2020 Close Great product This cytokine was used to stimulate various immune cells extracted from spleen and bone marrow of mice for the past few years with great performance. From: Jin | Date: 21/07/2020 × Great product This cytokine was used to stimulate various immune cells extracted from spleen and bone marrow of mice for the past few years with great performance. From: Jin | Date: 21/07/2020 Close mGMCSF Great for deriving DCs from BM. From: Kevin | Date: 26/08/2020 × mGMCSF Great for deriving DCs from BM. From: Kevin | Date: 26/08/2020 Close BMDCs we used this product for BMDCs in vitro maduration. From: Aitziber | Date: 26/08/2020 × BMDCs we used this product for BMDCs in vitro maduration. From: Aitziber | Date: 26/08/2020 Close
