Recombinant Murine GM-CSF 4 ReviewsSubmit a Review Product Details Catalogue Number: 315-03 Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues. Source: E.coli Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α AA Sequence: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 14.2 kDa Accession Number: P01587 Gene ID: 12981 crossreactivity: Bacteria, Human, Leech, Mouse, Rat, Trout References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Naqvi, A R Title miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells. Citation Scientific Reports; 6 pg32925 PubMed Id 27611009 First Author Sebollela, A Title Heparin-binding sites in granulocyte-macrophage colony-stimulating factor. Localization and regulation by histidine ionization. Citation The Journal of Biological Chemistry; 280(36) pg31949-56 PubMed Id 16027123 First Author Platt, R J Title CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Citation Cell; 159(2) pg440-55 PubMed Id 25263330 product.subtitle.productreviews Existing reviews Excellent product We have been using this product for 2 yrs for Bone marrow derived dendritic cell experiments and I never disappointed with the results. I highly recommend this product to our collaborators. From: Chetan | Date: 08/07/2020 × Excellent product We have been using this product for 2 yrs for Bone marrow derived dendritic cell experiments and I never disappointed with the results. I highly recommend this product to our collaborators. From: Chetan | Date: 08/07/2020 Close Great product This cytokine was used to stimulate various immune cells extracted from spleen and bone marrow of mice for the past few years with great performance. From: Jin | Date: 21/07/2020 × Great product This cytokine was used to stimulate various immune cells extracted from spleen and bone marrow of mice for the past few years with great performance. From: Jin | Date: 21/07/2020 Close mGMCSF Great for deriving DCs from BM. From: Kevin | Date: 26/08/2020 × mGMCSF Great for deriving DCs from BM. From: Kevin | Date: 26/08/2020 Close BMDCs we used this product for BMDCs in vitro maduration. From: Aitziber | Date: 26/08/2020 × BMDCs we used this product for BMDCs in vitro maduration. From: Aitziber | Date: 26/08/2020 Close
