Growth Factors & Cytokines

Recombinant Murine IL-13

Product Details

Catalogue Number: 210-13
Description:

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 are cross-species reactive.  Recombinant Murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.

Source: E.coli

Synonyms: NC300 (Human), P600 (Murine)

AA Sequence: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 4.0 ng/ml, corresponding to a specific activity of ≥ 2.5 x 105 units/mg.

Calculated Molecular Weight: 12.3 kDa

Accession Number: P20109

Gene ID: 16163

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Drurey, C
Title
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Citation
The Journal of Experimental Medicine; 219(1)
PubMed Id
First Author
Willenborg, S
Title
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Citation
Cell Metabolism; 33(12) pg2398-2414.e9
PubMed Id
First Author
Fremder, M
Title
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Citation
Cell Reports; 36(6) pg109521
PubMed Id

product.subtitle.productreviews

Existing reviews
Works great for our research!
We exclusively use Peprotech's recombinant proteins (human and murine). They have always performed well in our experiments and we have not had any issues yet.
From:  Kristen | Date:  08/07/2020