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Animal-Free Cytokines

Animal-Free Recombinant Murine IL-2

Product Details

Catalogue Number: AF-212-12
Description:
Animal-Free Recombinant Murine IL-2

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: T-cell growth factor, (TCGF), Aldesleukin

AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Animal-Free Recombinant Murine IL-2 Biological Activity Graph Animal-Free Recombinant Murine IL-2 WHO Competitor Graph

Calculated Molecular Weight: 17.2 kDa

Accession Number: P04351

Gene ID: 16183

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Fiancette, R
Title
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity
Citation
Nature Immunology; 22(10) pg1245-1255
PubMed Id
First Author
Cardoso, F
Title
Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit
Citation
Nature; 597(7876) pg410-414
PubMed Id
First Author
Cui, J
Title
IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation.
Citation
Cell Death & Disease; 12(6) pg501
PubMed Id

product.subtitle.productreviews

Existing reviews
Best cytokine of its kind
Have used this cytokine for T cell expansion. Very reliable and efficient. Gives good results every time.
From:  Vineet | Date:  26/08/2020