Animal-Free Recombinant Murine IL-3 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-213-13 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of mouse NFS-60 cells is ≤0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.1 kDa Accession Number: P01586 Gene ID: 16187 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Gerbil, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author De Munck, S Title Structural basis of cytokine-mediated activation of ALK family receptors Citation Nature; 600(7887) pg143-147 PubMed Id 34646012 First Author Quambusch, L Title Cellular model system to dissect the isoform-selectivity of Akt inhibitors Citation Nature Communications; 12(1) pg5297 PubMed Id 34489430 First Author Moccia, M Title Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases Citation Scientific Reports; 11(1) pg16103 PubMed Id 34373541
