Animal-Free Recombinant Murine IL-4 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-214-14 Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1) AA Sequence: MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 13.5 kDa Accession Number: P07750 Gene ID: 16189 crossreactivity: Mouse, Pig Intestinal Worm, Rat, Trout References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids COVID-19 Apoptosis Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Ishii, H Title Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Citation Cell death & disease; 3 pge363 PubMed Id 22875000 First Author Dunkle, A Title Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. Citation Cell death & disease; 2 pge214 PubMed Id 21975296 First Author Roux, C Title Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1. Citation Proceedings of the National Academy of Sciences of the United States of America; 116(10) pg4326-4335 PubMed Id 30770442
