Recombinant Murine IL-5 0 ReviewsSubmit a Review Product Details Catalog Number: 215-15 Description: IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains. Source: E.coli Synonyms: EDF, BCDFII, TRF AA Sequence: MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 26.2 kDa Accession Number: P04401 Gene ID: 16191 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Immune System Inflammation Wound Healing Allergy Recent Citations First Author Wigton, E J Title MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination. Citation The Journal of Experimental Medicine; 218(11) PubMed ID 34586363 First Author Onodera, T Title A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site. Citation Immunity; 54(10) pg2385-2398.e10 PubMed ID 34508662 First Author Patial, S Title Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs. Citation Scientific Reports; 11(1) pg15465 PubMed ID 34326406
