Animal-Free Cytokines

Animal-Free Recombinant Murine IL-6

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Product Details

Catalogue Number: AF-216-16
Description:
Animal-Free Recombinant Murine IL-6

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.  Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions.  It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism.  IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130.  Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.  Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 21.7 kDa

Accession Number: P08505

Gene ID: 16193

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Duan, H
Title
CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.
Citation
Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(13) pge2103719
PubMed Id
First Author
Fiancette, R
Title
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity
Citation
Nature Immunology; 22(10) pg1245-1255
PubMed Id
First Author
Sapra, L
Title
Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.
Citation
Scientific Reports; 11(1) pg1807
PubMed Id