Animal-Free Recombinant Murine IL-6 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-216-16 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 21.7 kDa Accession Number: P08505 Gene ID: 16193 crossreactivity: Human + Mouse, Monkey, Mouse, Mouse + Bacteria, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Yang, R Title IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b Citation Cell Death & Disease; 11(7) pg603 PubMed Id 32733020 First Author Xia, S Title T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia. Citation ACS Medicinal Chemistry Letters; 2020 Oct;17(10):1042-1052. PubMed Id 31431692 First Author Chen, J Title TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response Citation Nature Communications; 11(1) pg1913 PubMed Id 32312989
