Recombinant Murine IP-10 (CXCL10) 0 ReviewsSubmit a Review Product Details Catalog Number: 250-16 Description: IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: γ-Interferon Inducible Protein-10, CXCL10, crg-2 AA Sequence: IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1:Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10.0 ng/ml. Assay #2: Determined by its ability to chemoattract CXCR3-transfected HEK293 cells using a concentration range of 100-500 ng/ml. Calculated Molecular Weight: 8.7 kDa Accession Number: P17515 Gene ID: 15945 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Human, Monkey, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Transplantation Recent Citations First Author Du, Y Title Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Citation The Journal of Experimental Medicine; 219(7) PubMed ID 35640018 First Author Galeano Niño, J L Title Cytotoxic T cells swarm by homotypic chemokine signalling. Citation eLIFE; 9 PubMed ID 33046212 First Author Gopinath, S Title Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy. Citation Journal of immunology (Baltimore, Md. : 1950); 204(7) pg1703-1707 PubMed ID 32122994
