Chemokines

Recombinant Murine IP-10 (CXCL10)

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Product Details

Catalogue Number: 250-16
Description:


Recombinant Murine IP-10 (CXCL10)

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: γ-Interferon Inducible Protein-10, CXCL10, crg-2

AA Sequence: IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1:Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10.0 ng/ml.
Assay #2: Determined by its ability to chemoattract CXCR3-transfected HEK293 cells using a concentration range of 100-500 ng/ml.

Calculated Molecular Weight: 8.7 kDa

Accession Number: P17515

Gene ID: 15945

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Shin, H
Title
CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.
Citation
Nature Communications; 7 pg13346
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First Author
Campanella, G S
Title
CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10).
Citation
The Journal of Biological Chemistry; 278(19) pg17066-74
PubMed Id
First Author
Ha, Y
Title
Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma.
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Cell death & disease; 6 pge1900
PubMed Id