Growth Factors & Cytokines

Recombinant Murine Leptin

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Product Details

Catalogue Number: 450-31
Description:


Recombinant Murine Leptin

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues.

Source: E.coli

Synonyms: Obesity protein (OB)

AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Calculated Molecular Weight: 16.2 kDa

Accession Number: P41160

Gene ID: 16846

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zhang, L
Title
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.
Citation
Nature Communications; 9(1) pg4722
PubMed Id
First Author
Shiuchi, T
Title
Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β
Citation
Scientific Reports; 7(1) pg15141
PubMed Id
First Author
Hong, C
Title
ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.
Citation
PLoS ONE; 5(12) pge15333
PubMed Id