Growth Factors & Cytokines

Recombinant Murine LIGHT

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Product Details

Catalogue Number: 315-12
Description:
Recombinant Murine LIGHT

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain.

Source: E.coli

Synonyms: TNFSF14, HVEM-L

AA Sequence: MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its cytotoxic effecton HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-γ.

Calculated Molecular Weight: 20.1 kDa

Accession Number: Q9QYH9

Gene ID: 50930

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Waldemer-Streyer, R J
Title
Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration.
Citation
Cell death & disease; 6 pge2026
PubMed Id
First Author
Pontejo, S M
Title
Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.
Citation
The Journal of Biological Chemistry; 290(26) pg15973-84
PubMed Id
First Author
Fan, K
Title
Preparation and characterization of a monoclonal antibody against the protein LIGHT.
Citation
Hybridoma (2005); 24(6) pg309-13
PubMed Id