Chemokines

Recombinant Murine SDF-1β (CXCL12)

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Product Details

Catalogue Number: 250-20B
Description:


Recombinant Murine SDF-1beta (CXCL12)

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1β protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Murine SDF-1β is an 8.5 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

AA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 50.0-100.0 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: P40224

Gene ID: 20315

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Saia, M
Title
AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells.
Citation
Scientific Reports; 6 pg34957
PubMed Id
First Author
Liu, H
Title
Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.
Citation
The Journal of Biological Chemistry; 283(45) pg30642-9
PubMed Id
First Author
Cruz-Zárate, D
Title
Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
Citation
Scientific Reports; 11(1) pg7197
PubMed Id