Recombinant Murine TPO 1 ReviewsSubmit a Review Product Details Catalog Number: 315-14 Description: TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Source: E.coli Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF AA Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 18.7 kDa Accession Number: P40226 Gene ID: 21832 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cell Culture Immune System Stem Cells & Differentiation Wound Healing Recent Citations First Author Ahmed, N Title Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation. Citation The Journal of Experimental Medicine; 219(1) PubMed ID 34817548 First Author Abbonante, V Title Ablation of collagen VI leads to the release of platelets with altered function. Citation Blood Advances; 5(23) pg5150-5163 PubMed ID 34547769 First Author Gerosa, R C Title CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis. Citation Blood Advances; 5(23) pg5002-5015 PubMed ID 34581809 Product Reviews Existing reviews Recombinant Murine SCF We use this product in our mouse media, it works well! From: Nichole | Date: 26/08/2020 × Recombinant Murine SCF We use this product in our mouse media, it works well! From: Nichole | Date: 26/08/2020 Close
