Recombinant Murine VEGF165 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-32 Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Murine VEGF 165 is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. Source: E.coli Synonyms: Vascular Endothelial Growth Factor, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A AA Sequence (monomer): MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml. Calculated Molecular Weight: 39 kDa Accession Number: Q00731 Gene ID: 22339 crossreactivity: Chicken, Human, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Stem Cells & Differentiation product.subtitle.recentcitations First Author He, H Title Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Citation Blood; 136(2) pg183-198 PubMed Id 32305041 First Author Kauts, M Title In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation. Citation Stem Cell Reports; 10(1) pg151-165 PubMed Id 29276152 First Author de Mingo Pulido, à Title TIM-3 Regulates CD103 Citation Cancer Cell; 33(1) pg60-74.e6 PubMed Id 29316433
