Animal-Free Recombinant Rat GM-CSF 0 ReviewsSubmit a Review Product Details Catalog Number: AF-400-23 Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α AA Sequence: MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED50 is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg. Calculated Molecular Weight: 14.5 kDa Accession Number: P48750 Gene ID: 116630 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Wound Healing Recent Citations First Author Togni, M Title The adapter protein ADAP is required for selected dendritic cell functions. Citation Cell communication and signaling : CCS; 10(1) pg14 PubMed ID 22672517 First Author Li, X Title Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection. Citation PLoS ONE; 7(8) pge43512 PubMed ID 22927979 First Author Choudhury, M E Title A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats. Citation Brain and Behavior; 1(1) pg26-43 PubMed ID 22398979
