Growth Factors & Cytokines

Recombinant Rat IFN-γ

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Product Details

Catalogue Number: 400-20
Description:


Recombinant Rat IFN-gamma

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Rat IFN-γ is a 15.6 kDa protein containing 135 amino acid residues.

Source: E.coli

Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF

AA Sequence: MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse WEHI-279 cells.

Calculated Molecular Weight: 15.6 kDa

Accession Number: P01581

Gene ID: 25712

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zhou, Y
Title
Bidirectional modulation between infiltrating CD3
Citation
Scientific Reports; 8(1) pg51
PubMed Id
First Author
van Kasteren, S I
Title
Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 106(1) pg18-23
PubMed Id
First Author
Papageorgiou, I E
Title
TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 113(1) pg212-7
PubMed Id