Recombinant Rat IL-3β 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-03 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Rat IL-3β is a 16.3 kDa globular protein containing 144 amino acid residues. Source: E.coli Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg. Calculated Molecular Weight: 16.3 kDa Accession Number: P97688 Gene ID: 24495 crossreactivity: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Charles, N Title p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells. Citation The Journal of Biological Chemistry; 279(13) pg12312-8 PubMed Id 14715661 First Author Choudhury, M E Title A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats. Citation Brain and Behavior; 1(1) pg26-43 PubMed Id 22398979 First Author Yu, W Title Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo. Citation Carcinogenesis; 29(9) pg1717-24 PubMed Id 18453543
