Recombinant Rat M-CSF 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-28 Description: M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Rat M-CSF is a 36.2 kDa homodimeric protein consisting of two 155 amino acid polypeptide subunits. Source: E.coli Synonyms: Macrophage Colony Stimulating Factor, CSF-1, MGI-IM AA Sequence (monomer): MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 5.0 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg. Calculated Molecular Weight: 36.2 kDa Accession Number: Q8JZQ0 Gene ID: 78965 crossreactivity: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Shang, X Title R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. Citation The Journal of Biological Chemistry; 286(27) pg24068-78 PubMed Id 21572048 First Author Li, J Title VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. Citation Nature Communications; 8(1) pg1322 PubMed Id 29109438 First Author Petersen, M A Title Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Citation Neuron; 96(5) pg1003-1012.e7 PubMed Id 29103804
