Recombinant Rat MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalog Number: 400-12 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Rat MCP-1 is a 14.0 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 14 kDa Accession Number: P14844 Gene ID: 24770 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. Cross Reactivity Cited in References: Human, Human + Rat, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Recent Citations First Author Speth, J M Title Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. Citation Journal of immunology (Baltimore, Md. : 1950); 196(12) pg5112-20 PubMed ID 27183597 First Author Szmydynger-Chodobska, J Title Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier. Citation Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; 32(1) pg93-104 PubMed ID 21829211 First Author Hinojosa, A E Title CCL2/MCP-1 modulation of microglial activation and proliferation. Citation Journal of Neuroinflammation; 8 pg77 PubMed ID 21729288
