Recombinant Rat MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-12 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Rat MCP-1 is a 14.0 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 14 kDa Accession Number: P14844 Gene ID: 24770 Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Human + Rat, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Chen, S Title In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II. Citation The Journal of Experimental Medicine; 188(1) pg193-8 PubMed Id 9653095 First Author Hinojosa, A E Title CCL2/MCP-1 modulation of microglial activation and proliferation. Citation Journal of Neuroinflammation; 8 pg77 PubMed Id 21729288 First Author Chen, X L Title Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Citation Circulation Research; 83(9) pg952-9 PubMed Id 9797345
