Recombinant Rat MIP-1α (CCL3) 0 ReviewsSubmit a Review Product Details Catalog Number: 400-15 Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Rat MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1α, CCL3, LD78α AA Sequence: APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/ml. Assay #2: Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P50229 Gene ID: 25542 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Human + Rat, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation Recent Citations First Author Rius, C Title Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation. Citation Journal of immunology (Baltimore, Md. : 1950); 185(6) pg3718-27 PubMed ID 20709957 First Author Abu-Taha, M Title Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. Citation Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1393-402 PubMed ID 19553526 First Author Altomonte, J Title Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells. Citation Cancer Gene Therapy; 16(3) pg266-78 PubMed ID 18846115
